How Semaglutide Stacks Up Against Other Weight Loss Drugs and Protocols
How Semaglutide Stacks Up Against Other Weight Loss Drugs and Protocols
If you're looking to lose weight, you've probably considered a wide range of options, from fad diets to workout regimens to weight loss drugs. But how effective are these different strategies, and how do they stack up against each other?
In this article, we'll take a close look at semaglutide and compare it to other weight loss drugs and protocols in terms of effectiveness.
First, let's define our terms.
When we talk about weight loss drugs, we're referring to medications that are specifically designed to help people lose weight. Some of the most popular weight loss drugs on the market today include phentermine, lorcaserin, and orlistat. Each of these drugs works in a different way to help people shed pounds.
Weight loss protocols, on the other hand, refer to a broader range of strategies that people use to lose weight. This might include anything from cutting out certain foods to following a specific exercise plan to tracking calories and macros. While weight loss protocols don't involve prescription drugs, they can be highly effective when followed correctly.
Now, let's dive into the data.
According to a recent study published in the New England Journal of Medicine, semaglutide is one of the most effective weight loss drugs currently available. In the study, participants who took semaglutide lost an average of 15% of their body weight over the course of 68 weeks. That's an impressive result, especially when you consider that many other weight loss drugs on the market today are much less effective.
So where does semaglutide rank in comparison to other weight loss drugs and protocols?
To answer that question, we'll look at data from a variety of sources and rank the most popular weight loss strategies in terms of effectiveness.
Semaglutide: As we just discussed, semaglutide is one of the most effective weight loss drugs on the market today. In addition to the 15% weight loss seen in the NEJM study, other research has shown that semaglutide can reduce the risk of cardiovascular disease and improve glycemic control in people with type 2 diabetes.
Bariatric surgery: While not technically a weight loss drug or protocol, bariatric surgery is one of the most effective ways to lose weight for people with severe obesity. In one study, patients who underwent bariatric surgery lost an average of 28% of their body weight after two years.
Liraglutide: Another GLP-1 receptor agonist like semaglutide, liraglutide has been shown to help people lose an average of 8% of their body weight over the course of 56 weeks. While not quite as effective as semaglutide, liraglutide is still considered one of the top weight loss drugs on the market today.
Orlistat: Orlistat is a fat-blocking drug that helps people lose weight by preventing the absorption of dietary fat. While not as effective as some other weight loss drugs, orlistat can still help people lose an average of 5% of their body weight over the course of 12-57 weeks.

Here are the rankings of the weight loss drugs and protocols based on their effectiveness:
Semaglutide: In clinical trials, semaglutide has shown to be highly effective in promoting weight loss. Patients taking semaglutide lost an average of 15-20% of their body weight over 68 weeks.
Combination Therapy (Phentermine and Topiramate): This combination therapy has been shown to result in an average weight loss of 8-10% of body weight over 56 weeks.
Orlistat: Orlistat inhibits the absorption of dietary fat, resulting in an average weight loss of 5-10% of body weight over 12-57 weeks.
Liraglutide: Liraglutide has been shown to result in an average weight loss of 5-10% of body weight over 56 weeks.
Lifestyle Interventions (Diet and Exercise): Lifestyle interventions can result in an average weight loss of 5% of body weight over 6 months to a year.
Bariatric Surgery: Bariatric surgery can result in an average weight loss of 25-35% of body weight over 2 years.
It is important to note that the effectiveness of these weight loss interventions may vary depending on individual factors such as age, sex, and comorbidities. It is recommended that individuals consult with a healthcare professional to determine the best weight loss plan for their specific needs.
If you would like to learn more about weight loss options, including semaglutide, please book a consultation with us online. We offer both in-clinic visits for those local to the DFW area and telehealth consultations for those outside the area.
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